Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves

  • Mcmillan Hayley
  • Lundy Fionnuala
  • Dunne Orla
  • Al‐natour Banan
  • Jeanneau Charlotte
  • About Imad
  • Curtis Tim M
  • El Karim Ikhlas

  • Dental pulp
  • Human
  • MrgprX1
  • Nociception
  • Peripheral neurons


Mas-related G-protein-coupled receptor X1 (MrgprX1) is a human-specific Mrgpr and its expression is restricted to primary sensory neurons. However, its role in nociception and pain signaling pathways is largely unknown. This study aims to investigate a role for MrgprX1 in nociception via interaction with the pain receptor, Transient Receptor Potential Ankyrin 1 (TRPA1), using in-vitro and in-vivo human neuronal models. MrgprX1 protein expression in human trigeminal nociceptors was investigated