Understanding and optimizing the dynamics of the musculoskeletal and osteoarticular system
The BioMechanics/BioEngineering (BMI) team develops interdisciplinary scientific projects on the tissues of the osteoarticular and musculoskeletal systems and their interactions with movement. The objective and the originality of the BMI team is to study the healthy, pathological or repaired system by an integrated multidisciplinary, multi-scale and multi-physics approach marked by strong links between biomechanists, biologists, biomaterials specialists and clinicians.
Key words: Mechanics of and for the living, Biomechanics of motion, Numerical modeling and simulation, Mechanobiology, Tissue engineering, Mechanics for bioengineering
The BMI team, under the responsibility of Martine Pithioux (DR, CNRS) and Guillaume Rao (PR, AMU), has been built around two crossed axes:
1) "Mechanobiology" axis ; Resp. : Pierre Champsaur (PU-PH, AMU) & Jean-Louis Milan (MCF-HDR, AMU)
Mechanobiology line aims to understand the dynamics and plasticity of the tissue structures that constitute the musculoskeletal and osteoarticular system, as a function of mechanical and biological contexts. This line develops in vivo, in vitro and in silico combined researches. The challenge is to identify strategies for stimulating the processes of tissue regeneration and repair in order to restore movement.
The Mechanobiology line is divided in three main projects:
- Guiding the dynamics of bone regeneration
- Understanding the dynamics of "tissues at the interface" to reverse their degradation and pathological remodeling
- Improving diagnosis & monitoring of tissue dynamics by imaging
2) "Integrative biomechanics" axis ; Resp. : Jean-Noël Argenson (PU-PH, AMU) & Benjamin Goislard de Monsabert (MCF, AMU)
The "integrative biomechanics" focuses on understanding the individual dynamic adaptations of the musculoskeletal and osteoarticular systems during the production of movement to optimize ergonomic, sports and clinical intervention contexts.
The work of the team is oriented around the realization of three projects:
- Biomechanical adaptations to constraints
- Individualized study of movement for prevention
- Assisted surgery through simulation of internal mechanical constraints (hand, foot, tibial osteotomy, meniscus reconstruction, knee arthroplasty...)