Identification and validation of novel biomarkers and therapeutics for pulpitis using connectivity mapping

  • Al‐natour Banan
  • Rankin Robby
  • Mckenna Robyn
  • Mcmillan Hayley
  • Zhang Shu‐dong
  • About Imad
  • Khan Asma
  • Galicia Johnah C
  • Lundy Fionnuala
  • El‐karim Ikhlas
  • Sd Zhang
  • El Ikhlas

  • Irreversible pulpitis
  • Vital pulp therapy
  • SsCMap
  • Vital pulp treatment
  • Fluvastatin
  • Dequalinium chloride
  • Pulp capping


Aim To create an irreversible pulpitis gene signature from microarray data of healthy and inflamed dental pulps, followed by a bioinformatics approach using connectivity mapping to identify therapeutic compounds that could potentially treat pulpitis. Methodology The Gene Expression Omnibus (GEO) database, an international public repository