Clinical effectiveness of osteoporosis treatment in older patients: A fracture liaison service-based prospective study

  • Mugnier Benedicte
  • Daumas Aurélie
  • Couderc Anne-Laure
  • Mizzi Barbara
  • González Thomas
  • Amrani Anne
  • Lévêque Pierre
  • Aymes Brice
  • Argenson Jean-Noël
  • Villani Patrick

  • Fracture liaison service
  • Older people
  • Osteoporotic fracture prevention


The clinical efficacy of anti-osteoporotic treatments in old patients is discussed. The aim of this study was to assess if the use of anti-osteoporotic treatments for the secondary prevention of osteoporotic fractures could reduce the risk of refractures in patients over 75 years old in a Fracture Liaison Service. In this population of frail, elderly patients presenting with a recent osteoporotic fracture, we observed that the refracture incidence was similar in the treated group and the untreated group during the first year. However, 30 months after the index fracture, the osteoporosis medication for a year or more reduced the incidence of refractures by 70%.